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first_imgShin-Ichi Konno’s Cherubim concept bikeCausing constant roadblocks at NAHBS was Cherubim master builder Shin-Ichi Konno’s concept track bike.Though it must break about every single rule in the UCI book, the aerodynamic bike is intended as a thought experiment for the track bike of the future. “We’re too wedded to the traditional diamond-shaped bike,” said Konno when talking to BikeRumor. “We have to challenge accepted designs. That’s why I’ve made a bike like this.”Konno comes from an illustrious line of Japanese framebuilders. His father started Cherubim in the 1960s, and his father’s brothers were the creative talents behind San Rensho and Miyuki, famed for their Keirin-certified track bikes.The frame took around four days to design, and features a bespoke chromed seatpost and… one hesitates to say handlebars, so perhaps hand-rests would be better?It was difficult to find the space to get decent pictures, but we’ll return to the stand early tomorrow, to grab some close-up shots for you when there’s nobody else about.last_img read more

first_imgMarc Bruni(Photo: Emilio Madrid for Broadway.com) from $59.00 Related Shows View Commentscenter_img Trevor Trevor, a new musical based on the Academy Award-winning short film of the same name, will arrive at off-Broadway’s Stage 42 this spring. Beautiful: The Carole King Musical collaborators Marc Bruni and Joshua Prince will direct and choreograph the production, set to begin performances in April.Trevor features a book and lyrics by Dan Collins and music by Julianne Wick Davis (who together penned the 2016 musical adaptation of the documentary Southern Comfort). Based on an original story by James Lecesne, the show follows 13-year-old Trevor, a force of nature with a vivid imagination. As he deals with becoming a teenager, he struggles to navigate his own identity and determine how he fits into a challenging world.The nonprofit Trevor Project, the nation’s only accredited crisis intervention and suicide prevention organization focused on saving LGBTQ lives, was created as a result of the Trevor film.The off-Broadway staging of Trevor follows a 2017 world premiere mounting at Chicago’s Writers Theatre. Casting and a start date for the New York production will be announced soon.last_img read more

first_imgBy Brennan DialBishop Miege on Friday showed Basehor-Linwood why they’ve earned the number one ranking among 4A teams in Kansas.The 7-2 Bobcats were the latest team to bear the brunt of the Stags’ offensive power, as Miege extended its winning streak this season to 10 games with a 63-0 drubbing that moves them into the second game of the playoffs.The Stags showed off their high-power offense early, scoring on their first three drives and essentially putting the game out of reach by the end of the first quarter.“Coach wanted us to be up 21-0 in the first and that is what we did,” junior wide receiver Danny Murphy said after the game.Remarkably, Miege was able to top their play from the first quarter in the second, scoring another 28 unanswered points.[pullquote]Miege coach Jon Holmes discusses his team’s dominating performance against Basehor-LinwoodClick the arrow to hear Miege coach Jon Holmes talk about his team’s focus in the playoff opening win.Audio Playerhttps://dfv6pkw99pxmo.cloudfront.net/wp-content/uploads/2014/11/63-0.mp300:0000:0000:00Use Up/Down Arrow keys to increase or decrease volume.[/pullquote]Miege coach Jon Holmes said his team to a “nothing guaranteed” attitude into the playoff opener, and was focused on its goal of advancing to the state title game.“We challenge the guys you know we want to get a plaque every week.” Coach Holmes said after the game, “We have three more to get.”Junior running back Dawson Downing scored the first two touchdowns of the game and tallied 77 yards before exiting the game with an injury. Junior running back Ray Vaca replaced Downing, and led the team in rushing yards at the end of the night. Vaca was able to haul in passes for an additional 56 yards and a receiving touchdown.The offense for Miege totaled 467 total yard while just allowing 150 for Basehor-Linwood.“It was a key football game for us,” said senior safety Keegan Wilson, “and we played our keys perfectly.”The Stags will travel to Fort Scott next week to take on an 8-1 Tigers squad that beat Baldwin in its first playoff game.last_img read more

first_imgGlamour: Yeah, we all know there’s no such thing as the perfect guy (OK, maybe 69 percent perfect), but when we’re happy and in love, some of us think our guys are sent from heaven above. And while in the past, there have been conflicting reports on whether idealizing your partner is actually beneficial for your relationship, a new study in Psychology Today says it helps to keep the love alive—even after you say “I do.”The study, published in Psychological Science, looked at how idealizing partners impacted marriage satisfaction by following 193 newlyweds over three years. Researchers then asked participants to rate their partners, themselves and their “ideal” mates.Read the whole story: Glamour More of our Members in the Media >last_img read more

first_imgPinterest Share on Facebook Share on Twitter Email The Dutch famine of 1944 was a terrible time for many in the Netherlands – with around 4.5m people affected and reliant on soup kitchens after food supplies were stopped from getting into the area by German blockades. As many as 22,000 people were thought to have died, and those who survived would find it extremely difficult to ever fully recover.The dietary intake of people in affected areas was reduced from a healthy 2000 calories a day to a measly 580 – a quarter of the “normal” food intake. Unsurprisingly, without a balanced diet, children born to mothers who were pregnant during the famine showed a much lower than average birth weight.But then something strange happened: their children’s children had the same low birth weight, despite their mother’s “normal” food and calorie intake.center_img LinkedIn Share On top of this, daughters of women exposed to the Dutch famine were twice as likely to develop schizophrenia than the usually calculated risk. So what was happening?Welcome to epigeneticsWe often talk about our genetic make-up and “how good” or “how healthy” our genes are. We also know “bad genes” can lead to us having a higher chance of developing a particular disease if our parents are carriers. But while scientists can look for those faulty or changed genes, over the last decade we have learned this is not the whole story.Because it is not just our genes and DNA which determines our health, but also environmental factors such as diet, stresses, and lifestyle choices – just like in the Netherlands.What is epigenetics?These environmental conditions, alongside the life experiences of our parents, grandparents, and even our great-grandparents, have been shown to flip “stop” and “go” signals which regulate pretty much every process taking place in our cells. These signals can then cause changes on top of the inherited DNA molecules which can determine our well being – hence the lower birth weight of babies only distantly related to the famine.Being humanEpigenetics takes the age-old question of “nature vs nurture” to a whole new level of scientific interest. But it is a controversial field of study with wide-reaching implications which could change everything we thought we knew about genetic inheritance.What we do know, though, is that the environment and our nutritional intake plays a crucial role in affecting changes to our DNA – which has been demonstrated by the effects of the Dutch famine. The famine has shown how changes in epigenetic markers – the “stop” and “go” signals – are inherited, from parent to offspring and to their offspring in turn. This process is called transgenerational inheritance.The genes affected are ones that are important in processing nutrients and are associated with diseases such as diabetes or are implicated in mental health conditions such as schizophrenia and bipolar disorders.Studies on identical twins show how the environment and trauma can change these epigenetic flags. While the siblings were genetically identical, their identical epigenetics changed over time – essentially showing how environmental factors can alter genes which are linked to depression, anxiety and obesity.Recently, studies using mice, rats, fruit flies and worms have also shown that trauma and stress can affect these epigenetic flags which then get passed on to the next generation, and then on to the next.We know that if a female rat takes good care of her offspring, for example, then the pups are able to cope better with stress compared to rat pups that were ignored and had high levels of stress. In this instance, the removal of “stop” signals on a specific gene seems to be linked to happier offspring.Similarly, male mice who experience stress early in their lives pass this on, even to their grand pups – which are more likely to show symptoms of anxiety and depression, even if they were looked after well and grew up in a nurturing environment.Fixing the future?Studies in humans are difficult to control as generally we do not have a reference value for epigenetic markers before a trauma or stress, so we cannot make easy comparisons. But what we do know is that women who were pregnant while experiencing extremely stressful situations, such as the 9/11 attacks, apparently have passed on this experience to their child.Their children have reported experiencing depression, anxiety and poor coping mechanisms in stressful situations. Similarly, children and grandchildren of Holocaust victims often have mental health issues.But it isn’t all doom and gloom. We aren’t simply living at the mercy of our ancestors’ past lives because we do know that at least some of the epigenetic marks are reversible.We potentially can affect our epigenetics by living a healthy lifestyle and providing our body with the necessary building blocks for these epigenetic flags.Recent research also shows that drugs can remove negative epigenetic marks and remove “stop” signals – which has been shown to allow changed genes present in cancer, Alzheimer’s or diabetes to go back to theie original state.So while we may still be some way off fully understanding the role epigenetics plays in the “nature vs nurture” debate, one thing is clear: it’s not simply our genes that make us. So next time you’re feeling stressed or angry, or thinking about grabbing another takeaway pizza on the way home, think of your future grandchildren. It may save them a whole lot of bother.Karin Garrie, Lecturer/Senior Lecturer, Nottingham Trent UniversityThis article was originally published on The Conversation. Read the original article.last_img read more

first_imgCDC: 41 more measles cases raise total to 1,022The Centers for Disease Control and Prevention (CDC) reported 41 more measles cases in the past week, raising 2019’s total number of cases to 1,022, a record for the post-elimination era.”This is the greatest number of cases reported in the U.S. since 1992 and since measles was declared eliminated in 2000,” the CDC said today.Twenty-eight states have recorded cases, with several states reporting outbreaks, defined as three or more related cases. The biggest outbreaks have occurred in New York and New Jersey, with Washington state, California, and Pennsylvania also currently tracking outbreaks.The CDC said all seven ongoing outbreaks are related to international travel to countries currently experiencing outbreaks, including Israel, Ukraine, and the Philippines. The number of ongoing outbreaks, however, fell from 10 a week ago.The largest US outbreak is in New York City, which involves at least 566 measles cases since last September, primarily in the city’s Orthodox Jewish Brooklyn community.  Jun 10 CDC update Jun 3 NYC Health update MERS-CoV sickens 3 more in Saudi ArabiaOver the last 2 days Saudi Arabia’s health ministry reported three more MERS-CoV cases, all of them involving men from three different cities.One is a 55-year-old from Qusaiba in Al Qassim region in the central part of the country. It’s not known if he had contact with camels, and his exposure to MERS-CoV (Middle East respiratory syndrome coronavirus) is listed as secondary, meaning he likely contracted the virus from another patient.The second patient is a 65-year-old from Qaisoumah in Eastern region who had contact with camels, and the third is a 28-year-old from the city of Unaizah in Al Qassim region who also had contact with camels, a known risk factor for MERS-CoV.Saudi Arabia has now reported 150 MERS-CoV cases for the year. The World Health Organization said in its most recent global update for the disease as of the end of April it had received reports of 2,428 cases, at least 839 of them fatal, since the virus was first detected in humans in 2012. The vast majority are from Saudi Arabia.Jun 10 Saudi MOH epidemiological week 24 report ‘Blue ribbon’ panel issues recommendations on Cyclospora outbreaksA “blue ribbon” panel of experts commissioned by Fresh Express late last week issued interim recommendations for preventing and addressing Cyclospora outbreaks in the United States, including stepped-up assessment of water sources, personnel training, and data collection.After several produce suppliers, including Fresh Express, were hit with a Cyclospora cayetanensis outbreak in 2018, the first linked to US-grown produce, the company formed the blue-ribbon panel of 11 experts, headed by food safety expert Michael Osterholm, PhD, MPH director of the University of Minnesota’s Center for Infectious Disease Research and Policy (CIDRAP), which publishes CIDRAP News, and 16 other contributors.”The goal was to establish a Blue-Ribbon Panel to summarize state-of-the-art advancements regarding this public health challenge and to identify immediate steps that the produce industry and regulators can take to prevent future outbreaks,” Osterholm writes in the introduction to the report.The expert panel first met in November 2018, then formed four working groups to focus on root causes, preventive steps, collaboration, and testing validation. Recommendations developed by the working groups and included in the report are divided in prevention, incident response, and collaboration.The vast majority of Cyclospora outbreak cases in the United States have involved imported produce.Prevention advice in the report includes surveying environment water sources for Cyclospora contamination; properly training of farm crews about sanitation, hygiene, and waste management; and developing a fact sheet to raise awareness about the disease, which the experts released with the report. Incidence response steps including assessing farms for unsanitary conditions and probing the role that animals, especially birds, might play in contaminating water bodies. Collaboration improvements include enhanced communication between government and industry, and expanded lab capacity. The report includes 30 recommendations.”This is an exceptional collaboration by those most knowledgeable about a particular food safety risk,” Osterholm said in a Fresh Express news release. “Their value in shedding light on the Cyclospora cayetanensis outbreak problem cannot be overstated and is already providing long-needed assistance toward discovering how best to manage risk and limit future outbreaks.”Jun 5 blue-ribbon panel report Fresh Express report landing page Study: Chickenpox vaccine cuts shingles risk in childrenChildren who received the chickenpox vaccine are significantly less likely to contract shingles, according to large study based on electronic health records that appeared today in Pediatrics.The varicella vaccine’s impact against herpes zoster infection is well known, but researchers weren’t sure if the vaccine also had an impact against children’s shingles, for which symptoms are generally milder than the adult form of the disease, which is marked by a painful, burning, and blistering skin rash.For the study, a team led by Kaiser Permanente and funded by the CDC examined data on 6.3 million children from six integrated healthcare organizations between 2003 and 2016. About half of the children were vaccinated for some of all of period covered by the study.Over the 12-year study period, the shingles rate fell by 72% overall, as the number of vaccinated children rose. Incidence of shingles was 78% lower in vaccinated kids than their unvaccinated counterparts. The team also found that rates for children who were immunosuppressed and weren’t able to be vaccinated were 5 to 6 times higher than in kids who weren’t immunosuppressed.Sheila Weinmann, PhD, the study’s lead investigator who is with Kaiser Permanente Northwest’s Center for Health Research in Portland, Oregon, said in a press release that the highest shingles rates were in the early years of the study when there was a higher proportion of children, especially older ones, who weren’t vaccinated against chickenpox.Jun 10 Pediatrics abstract Jun 10 Pediatrics commentary Jun 10 Kaiser Permanente press release Study: Mid-Atlantic white-tailed deer more susceptible to CWDAccording to new research from Penn State University, white-tailed deer from Mid-Atlantic states are more susceptible to chronic wasting disease (CWD) than deer found to the west, likely because of genetic variants that make them more vulnerable to neurologic illnesses. The findings are published in BMC Genetics.The research is based on tissue samples collected from 720 white-tailed deer from an area encompassing Pennsylvania, Virginia, and Maryland. The samples were tested for 17 microsatellite loci markers. Microsatellite markers are short, repetitive DNA sequence elements, used to identify genetic differences. Eventually, the researchers selected 11 markers most likely to show susceptibility to CWD.”The genetic variants that would make deer less susceptible to chronic wasting disease are in much lower frequency in the East, likely because they weren’t needed,” said David Walter, PhD, adjunct assistant professor of wildlife ecology at Penn State and the lead author of the study, in a Penn State news release. “We have seen that deer with the more susceptible genotypes are in the majority.”White-tailed deer populations are larger in the Eastern and Mid-Atlantic parts of the United States, Walter said. In recent years, more states have reported growing numbers of CWD, a fatal prion disease, among deer populations. Jun 6 BMC Genetics study Jun 6 Penn State press releaselast_img read more

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first_imgNew regulations that may reduce transfer of undertakings protection of employment (TUPE) rights have been delayed to September, it emerged this week.The new regulations, which had been due for publication in July, arise from a Department for Business, Innovation & Skills consultation that began at the beginning of this year and considers the future of the service provision change (SPC) rules introduced in 2006. The Law Society’s employment law committee has been vociferous in its opposition to changing the SPC rules, as have many practitioners.Dr John McMullen, partner at Yorkshire firm Wrigleys, said: ‘Repealing the SPC rules will return the law to the state of affairs prior to 2006, which was an era of uncertainty in the application of TUPE to outsourcing. Litigation has definitely diminished since the introduction of the SPC rules and many consider the law to be much more straightforward than was previously the case.’The Law Society’s response to the consultation argued that repealing the 2006 amendments would increase litigation, and that the prescriptive nature of the employee liability obligation was the best way to ensure efficient transfers. It also said that it would be helpful for the categories of employee liability information to be expanded.last_img read more

first_imgSecret evidence about the extent of links between the UK and Saudi Arabia has helped kill off a legal challenge to the sale of weapons used in the conflict in Yemen. Ruling in Campaign Against Arms Trade v Secretary of State for International Trade today, Lord Justice Burnett and Mr Justice Haddon-Cave defend the use of secret hearings, so called closed material procedures. ‘The advantage of the closed material procedure is that we have had full access to all the facts and materials relied upon by the secretary of state,’ they state. These materials are considered in a secret ‘closed judgment’. The published judgment states: ‘It is sufficient to record here that the closed material, in our view, provides valuable additional support for the conclusion that the judgements made by the secretary of state were rational.’The action was brought by campaign group Campaign Against Arms Trade against the decision to continue granting export licences for arms including Typhoon strike aircraft to Saudi Arabia following the country’s intervention in neighbouring Yemen. At least 10,000 people have been killed since 2015 in the war against Iranian-backed forces.Amnesty International, Human Rights Watch, Rights Watch UK and Oxfam intervened in the action, which took evidence over a three-day hearing – half of which was closed. The claimants argued that the arms exports contravened the government’s policy because of the Saudi-led coalition had targeted civilians in Yemen. Dismissing the challenge, the judges ruled that the government had available ‘a much wider range of information’ than its non-governmental organisation critics. This included MoD-sourced imagery and defence Intelligence reports. ‘Much of this information is sensitive and necessarily cannot be referred to in detail in open session for national security reasons,’ the judgment states. According to the judgment, the Ministry of Defence ‘provides significant training to the Saudi armed forces in relation to targeting and compliance with international humanitarian law’.It concludes that the secretary of state for international trade ‘was rationally entitled to conclude’ that the coalition was not deliberately targeting civilians and that there was no ‘clear risk’ that there might be serious violations of international humanitarian law which would require arms sales to be suspended or cancelled.The Campaign Against the Arms Trade said it would appeal. Rosa Curling, associate at London firm Leigh Day, said: ‘The law is clear: where there is a clear risk UK arms might be used in the commission of serious violations of international law, arm sales cannot go ahead. Nothing in the open evidence presented by the UK government to the court suggests this risk does not exist in relation to arms to Saudi Arabia.’The claimant was represented by Martin Chamberlain QC & Conor McCarthy, instructed by Leigh Day Solicitors; the defendant by James Eadie QC, Jonathan Glasson QC, Kate Grange, Jessica Wells and Alex Cameron, instructed by the Government Legal Department.last_img read more